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Application of Classical Resolution for Separation of DL-Serine

✍ Scribed by V. S. Sistla; J. von Langermann; H. Lorenz; A. Seidel-Morgenstern

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
216 KB
Volume
33
Category
Article
ISSN
0930-7516

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✦ Synopsis

Abstract

For resolution of chiral compound‐forming substances diastereomeric salt formation is the most important classical separation technique. Diastereomeric salts possess different physical and chemical properties, e.g., solubilities, which facilitate the effective separation via crystallization. A maximum recovery of both diastereomeric salts is usually unachievable when there is a lack of quantitative information regarding solubility and metastable zone width. The present work provides experimental results for the formation of diastereomeric salts of DL‐serine. As basic thermodynamic data binary melting and ternary solubility phase diagrams are shown and discussed. A plan for a series of crystallization processes is suggested for the recovery of both salts in pure form with a maximum possible yield.

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