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Application of carboxylic-phospholanic mixed anhydrides to fragment coupling in peptide synthesis

✍ Scribed by POULOS, CONSTANTINE ;ASHTON, CHRIS P. ;GREEN, JEREMY ;OGUNJOBI, OLUYINKA M. ;RAMAGE, ROBERT ;TSEGENIDIS, THEODOROS


Book ID
115099325
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
614 KB
Volume
40
Category
Article
ISSN
0367-8377

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Trimethylsilyldiazomethane in the prepar
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Reaction of trimethylsilyldiazomethane with a mixed anhydride derived from a carboxylic acid by the action of ethyl chloroformate, yields the corresponding diazoketone in high yield. Subsequent Wolff rearrangement of the diazoketone leads to the homologated ester. Reaction of trimethylsilyldiazometh