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Application of automated serial blood sampling and dried blood spot technique with liquid chromatography–tandem mass spectrometry for pharmacokinetic studies in mice

✍ Scribed by Philip Wong; Roger Pham; Carl Whitely; Marcus Soto; Kevin Salyers; Christopher James; Bernd A. Bruenner


Book ID
113743096
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
390 KB
Volume
56
Category
Article
ISSN
0731-7085

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The methodology described demonstrates, for the first time, the feasibility of performing pharmacokinetic studies in the serially bled mouse model to support the early development of discovery compounds. Sample analysis, using capillary high performance liquid chromatography combined with tandem mas