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Application of arabinofuranosyl cytosine in the kinetic analysis and quantitation of DNA repair in human cells after ultraviolet irradiation

✍ Scribed by Snyder, R.D.; Carrier, W.L.; Regan, J.D.

Book ID: 118517964
Publisher: Biophysical Society
Year: 1981
Tongue: English
Weight: 780 KB
Volume: 35
Category: Article
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(81)84793-5

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## Abstract The cytotoxic effect of 1‐β‐D‐arabinofuranosyl cytosine (araC) depends on the intracellular phosphorylation into its active compound araCTP, on the degree of degradation of araCTP and on the incorporation of araCTP into DNA. Deoxycytidine triphosphate (dCTP) inhibits the phosphorylation