Application of anti-ssDNA monoclonal antibody to study exogenous and apoptosis-associated DNA damage

Binding of human anti-DNA autoantibodies

Binding of human anti-DNA autoantibodies to reactive oxygen species modified-DNA and probing oxidative DNA damage in cancer using monoclonal antibody

✍ Badithe T. Ashok; Rashid Ali 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 96 KB 👁 2 views

The binding of native and reactive oxygen species-modified DNA (ROS-DNA) to circulating antibodies in the serum of patients with various types of cancer has been investigated by competition enzyme-linked immunosorbent assay. Fifteen sera of 35 showed reactivity with native and/or ROS-DNA. Eleven of