Application of accelerator mass spectrometry (AMS) for high-sensitivity measurements of 14CO2 in long-term studies of fat metabolism
✍ Scribed by Kristina Stenström; Sigrid Leide-Svegborn; Bengt Erlandsson; Ragnar Hellborg; Sören Mattsson; Lars-Erik Nilsson; Bertil Nosslin; Göran Skog; Anders Wiebert
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 590 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0969-8043
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✦ Synopsis
Long-term measurements of 14C in CO2 expired after ingestion of 14C-labelled triolein were performed using accelerator mass spectrometry (AMS). About 30% of a given amount of 14C-labelled triolein was catabolized rapidly, while the remaining 70% had a very slow turnover. The study shows the potential of the AMS technique for the study of the long-term biokinetics of 14C-labelled pharmaceuticals. The AMS technique allows the administered activity to be reduced by several orders of magnitude without compromising the study. It may also allow studies of rare drug metabolites.