Application of a three-dimensional poroelastic BEM to modeling the biphasic mechanics of cell–matrix interactions in articular cartilage
✍ Scribed by Mansoor A. Haider; Farshid Guilak
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 921 KB
- Volume
- 196
- Category
- Article
- ISSN
- 0045-7825
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✦ Synopsis
Articular cartilage exhibits viscoelasticity in response to mechanical loading that is well described using biphasic or poroelastic continuum models. To date, boundary element methods (BEMs) have not been employed in modeling biphasic tissue mechanics. A threedimensional direct poroelastic BEM, formulated in the Laplace transform domain, is applied to modeling stress relaxation in cartilage. Macroscopic stress relaxation of a poroelastic cylinder in uni-axial confined compression is simulated and validated against a theoretical solution. Microscopic cell deformation due to poroelastic stress relaxation is also modeled. An extended Laplace inversion method is employed to accurately represent mechanical responses in the time domain.