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Application of a single-compartment model for estimation of styrene uptake from measurements of urinary excretion of mandelic and phenylglyoxylic acids after occupational exposure

✍ Scribed by Kent Wrangskog; Jan Sollenberg; Erik Söderman

Publisher: Springer-Verlag
Year: 1996
Tongue: English
Weight: 473 KB
Volume: 68
Category: Article
ISSN: 0340-0131
DOI: 10.1007/bf00409419

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✦ Synopsis

In biological monitoring of styrene, the exposure is usually related to the urinary concentration of mandelic (MA) and/or phenylglyoxylic (PGA) acids in a urine sample taken after the workshift or on following morning. To study this relationship further, a single-compartment mathematical model was developed by which measured occupational repetitive uptake of styrene during a working day was related to measured excretion rates of the urinary metabolites. The model was used in practice to calculate the unknown uptake (dose) from MA and PGA excretion analyzed in urine samples. For comparison, a styrene limit dose was calculated from the exposure limit. Analytical results of samples from plastic boat builders were compared with the limit values.

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Styrene exposure of 18 workers in fiberglass reinforced plastic industries was measured for 30-min periods throughout each workday for a week. The styrene uptake was estimated using pulmonary ventilation measurements. All urine voidings were collected separately and the styrene metabolites, mandelic