Application of a new LDL apheresis system using two dextran sulfate cellulose columns in combination with an automatic column-regenerating unit and a blood cell separator
✍ Scribed by Dr. W. Knisel; M. Müller; I. Besenthal; A. Di Nicuolo; M. Rebstock; T. Risler; M. Eggstein
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 488 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0733-2459
No coin nor oath required. For personal study only.
✦ Synopsis
Extracorporeal procedures for selective removal of low-density lipoprotcins have become a promising new approach for treatment of severe familial hypcrcholcsterolemia. Wc tested efficacy and safety of a new LDL apheresis system by using two dextran sulfate ccllulosc adsorbents (Liposorber LA 15TM from Kancgafuchi) under thc control of an automatic column-rcgenerating unit for continuous alternate adsorption and desorption. Plasma was taken from a continuous-fow blood cell scparator (model IBMiCobe 2997) allowing an cxtracorporeal circuit from one cubital vein to another. A 57-year-old maie with drug-resistant heterozypus familial hypercholestcroiemia accornpanicd by moderate hypertriglyceridemia and severe coronary artery disease has been treated evcry 2 weeks for 3 months so far. Treatmcnt of 4-5 liters of plasma resulted in a mean decrease of total cholestcrol from 355 to 11 1 mg/dl(9.20 to 2.88 mmolil), of LDL cholestcrol from 272 to 49 mg/dl (7.05 to 1.53 rnmolil), and of apolipoprotcin B from 175 to 44 mgidl. HDL cholestcrol. apolipoprotcin A-I. and other plasma protcins did not substantially change apart from hemodilution. No side cffects were secn. This new technique of LDL apheresis represents a very effectivc and safe method for treatmcnt of drug-resistant familial hypercholestcrolemia without or with concomitant hypertrigl yceridemia.