Evaluation of the reliability of nonline
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Yoshinori Onuki; Koichi Ohyama; Chosei Kaseda; Hiroaki Arai; Tatsuya Suzuki; Koz
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Article
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2008
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John Wiley and Sons
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English
β 377 KB
The response surface method incorporating multivariate spline interpolation (RSM-S) is a powerful technique for the formulation optimization of pharmaceuticals. However, no satisfactory method has been developed to evaluate the reliability of the optimal solution. We integrated bootstrap (BS) resamp