𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Application of a Double Mannich Reaction Using Bis(aminol) Ethers in the Synthesis of AE Ring Analogues of Methyl Lycaconitine.

✍ Scribed by Constanze Brocke; Margaret A. Brimble; Diana S.-H. Lin; Malcolm D. McLeod

Book ID
101971580
Publisher
John Wiley and Sons
Year
2005
Weight
20 KB
Volume
36
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

For Abstract see ChemInform Abstract in Full Text.

📜 SIMILAR VOLUMES

Efficient Synthesis of the Azabicyclo[3.
Efficient Synthesis of the Azabicyclo[3.3.1]nonane Ring System in the Alkaloid Methyllycaconitine Using Bis(alkoxymethyl)alkylamines as Aminoalkylating Agents in a Double Mannich Reaction
✍ Margaret A. Brimble; Constanze Brocke 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 214 KB

## Abstract The double Mannich reaction of cyclic β‐keto esters with bis(alkoxymethyl)alkylamines provides an efficient and versatile method for the construction of azabicyclo[3.3.1]nonanes and azabicyclo[3.2.1]octanes. The optimum conditions for efficient reaction involve use of the activator tric

In situ alcohol oxidation-Wittig reactio
In situ alcohol oxidation-Wittig reactions using N-methoxy-N-methyl-2-(triphenylphosphoranylidine)acetamide: application to the synthesis of a novel analogue of 5-oxo-eicosatetraenoic acid
✍ Leonie Blackburn; Hisashi Kanno; Richard J.K. Taylor 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 313 KB

Benzylic, allylic, propargylic and unactivated alcohols can be oxidised with activated manganese dioxide in the presence of N-methoxy-N-methyl-2-(triphenylphosphoranylidine)acetamide to generate directly the corresponding a,b-unsaturated Weinreb amides. Elaboration of the resulting Weinreb amides is