Application of 3,3′-disubstituted xylBINAP derivatives in inter- and intramolecular asymmetric Heck/Mizoroki reactions

✍ Scribed by Danica A. Rankic; Daniela Lucciola; Brian A. Keay

• Book ID: 104098251
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 287 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.08.078

✦ Synopsis

a b s t r a c t 3,3 0 -Disubstituted xylBINAP derivatives were applied to inter-and intramolecular asymmetric Heck/ Mizoroki reactions. The results from these reactions were compared to those obtained with (R)-xylBINAP, (S)-BINAP and 3,3 0 -disubstituted BINAP derivatives. Catalysts derived from 3,3 0 -disubstituted xylBINAP ligands were found to be most effective in the arylation of 2,3-dihydrofuran in terms of reaction times, conversions, and product enantioselectivity.