Application of [2,3]Wittig and [3,3]Claisen rearrangements in steroid side chain synthesis. A highly stereocontrolled entry to either (22 S)- or (22 R)-hydroxy-23-carboxylic acid

✍ Scribed by Ko¯lchi Mikami; Kazuya Kawamoto; Takeshi Nakai

• Publisher: Elsevier Science
• Year: 1986
• Tongue: French
• Weight: 216 KB
• Volume: 27
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)85092-3

✦ Synopsis

An efficient approach to either (22S)-or (22Ij)-hydroxy-23-carboxylic is described which relies on the stereochemical transmission via [2,3]Wittig sigmatropic rearrangement, respectively. acid side chain or [3,3]Claisen