✦ LIBER ✦
Application of 1H NMREu(fod)3shifted spectra for the determination of the enantiomeric composition and absolute configuration of secondary alcohols, using (−)-ω-camphanic esters
✍ Scribed by Janusz Jurczak; Andrzej Konował; Zbigniew Krawczyk; Andrzej Ejchart
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 265 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0749-1581
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The diastereomeric differences (Δδ) were measured for a series of 11 (−)‐ω‐camphanic esters of secondary alcohols of known absolute configuration, using ^1^H NMR spectroscopy with Eu(fod)~3~ as shift reagent. This method is convenient and useful for the measurement of enantiomeric compositions, whereas additional assumptions must be applied in determining the absolute configuration related to the signs of the diastereomeric differences.