Applicability of continuous membrane bioreactor in production of phenylacetylcarbinol

✍ Scribed by Michelle K. H. Liew; Anthony G. Fane; Peter L. Rogers

• Publisher: Wiley (John Wiley & Sons)
• Year: 1995
• Tongue: English
• Weight: 537 KB
• Volume: 64
• Category: Article
• ISSN: 0268-2575
• DOI: 10.1002/jctb.280640214

✦ Synopsis

A continuous membrane bioreactor (CMB) with Ceraflo ceramic microfilter was evaluated for the production of phenylacetylcarbinol (PAC) using 12-15 g dm-3 Candida utilis. Compared with the classical continuous fermentation, the CMB process was shown to have higher biomass concentration (from 40% to 400% increase) and greater growth rate (from 3-to 9-fold) at dilution rates varying from 0.03 h-' to 0.23 h-'. These advantages were partially offset by the reduced permeate flux caused by the increased biomass. Furthermore, an addition of only 3.0 cm3 h-' benzaldehyde for 17 h (a typical bioconversion protocol) was found to kill the yeast, resulting in 27% dead organisms and 35% lysed organisms and their associated species. This led to a 100% flux decline during the course of PAC production over the above period.