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APPG secretion in a rat phaeochromocytoma cell line (PC12)

✍ Scribed by Suzuki, H.; Tischler, A.S.; Christofides, N.D.; Chretien, M.; Polak, J.M.; Bloom, S.R.

Book ID
122583547
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
50 KB
Volume
9
Category
Article
ISSN
0167-0115

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## Abstract PC12 rat phaeochromocytoma cells show neuronal differentiation upon NGF treatment. NGF induces prolonged activation of the Ras/Raf/MEK/ERK pathway in which the 42/44 kDa mitogen‐activated protein kinases (MAPKs), ERK 1 and 2 are thought to be the key mediators of the differentiation sig