Appearance of hCG-receptor after conversion of newborn ovarian cells into testicular structures by H-Y antigen in vitro
✍ Scribed by U. Müller; Maria Teresa Zenzes; T. Bauknecht; U. Wolf; J. W. Siebers; W. Engel
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 268 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0340-6717
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✦ Synopsis
In a previous report (Zenzes et al., 1978b) it was shown that dissociated ovarian cells of newborn rats in vitro, if exposed to H-Y antigen, reorganize into testicular structures. The current study was designed to see whether this morphological conversion also results in a functional conversion. The LH/hCG receptor was used as a parameter characteristic for the newborn testis, but not for the newborn ovary. In the converted ovary, the LH/hCG receptor becomes detectable a few hours after onset of the culture and remains continuously present afterward. The appearance of this receptor may be due to a hormone-like action of H-Y antigen.