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Appearance of epithelial and stromal genomic instability in background colorectal mucosa of sporadic colorectal cancer patients: relation to age and gender

✍ Scribed by Harue Umeto; Tsutomu Yoshida; Kayo Araki; Hiroko Yagishita; Tetuo Mikami; Isao Okayasu


Book ID
106180529
Publisher
Springer Japan
Year
2009
Tongue
English
Weight
486 KB
Volume
44
Category
Article
ISSN
0944-1174

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## Abstract Disease expression in hereditary nonpolyposis colorectal cancer (HNPCC) cannot be readily explained by mutation site in the respective DNA mismatch repair genes associated with this disorder. One explanation is the role of modifying genes that can either promote or prevent disease devel