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Apparently balanced chromosome translocations and midline defects

โœ Scribed by Cowchock, Susan


Book ID
101445776
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
93 KB
Volume
33
Category
Article
ISSN
0148-7299

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## Abstract Activating mutations of the __PTPN11__ gene encoding the SHP2 tyrosine phosphatase is the most common genetic abnormality in juvenile myelomonocytic leukemia and is sporadically observed in myelodysplasia (MDS) and acute myeloid leukemia (AML). An unselected series of 140 patients with