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Apparent thermodynamic parameters of ligand binding to the cloned rat μ-opioid receptor

✍ Scribed by Jian-Guo Li; Robert B Raffa; Peter Cheung; Tsang-Bin Tzeng; Lee-Yuan Liu-Chen


Book ID
114016454
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
225 KB
Volume
354
Category
Article
ISSN
0014-2999

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Previous data obtained with the cloned rat µ opioid receptor demonstrated that the ''super-potent'' opiates, ohmefentanyl (RTI-4614-4) and its four enantiomers, differ in binding affinity, potency, efficacy, and intrinsic efficacy. Molecular modeling (Tang et al., 1996) of fentanyl derivatives bindi