Apparent solubility threshold densities of substituted coumarins
✍ Scribed by E.M. Calvey; S.W. Page; L.T. Taylor
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 580 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0896-8446
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✦ Synopsis
Apparent threshold densities were determined for a series of coumarin derivatives using a supercritical fluid chromatograph with a flame ionization detector. The extraction cell was an LC stainless steel precolumn. Milligram quantities of the model compounds were extracted. Coumarin functionality and extraction temperature affected the measured threshold densities. The addition of two hydroxyl groups onto the coumarin structure caused the compound to be unextractable at 60 "C with densities up to 0.90 g/mL. For those compounds that were completely extracted, coumarin, 7-methoxycoumarin, 3-phenylcoumarin, and psoralen, the apparent threshold density increased with increasing melting point.