## As part of a four-center NIMH Genetics Initiative on Bipolar Disorder, a genome screen using 365 markers was performed on 540 DNAs from 97 families, enriched for affected relative pairs. This is the largest uniformly ascertained and assessed linkage sample for this disease, and includes 232 subj
Apparent replication of suggestive linkage on chromosome 16 in the NIMH genetics initiative bipolar pedigrees
β Scribed by Dick, Danielle M. ;Foroud, Tatiana ;Edenberg, Howard J. ;Miller, Marvin ;Bowman, Elizabeth ;Rau, N. Leela ;DePaulo, J. Raymond ;McInnis, Melvin ;Gershon, Elliot ;McMahon, Francis ;Rice, John P. ;Bierut, Laura J. ;Reich, Theodore ;Nurnberger, John
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 82 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0148-7299
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As part of the four-center NIMH Genetics Initiative on Bipolar Disorder we carried out a genomic scan of chromosomes 3, 5, 15, 16,17, and 22. Genotyping was performed on a set of 540 DNAs from 97 families, enriched for affected relative pairs and parents where available. We report here the results o
## Abstract The NIMH genetics initiative on bipolar disorder was established to collect uniformly ascertained bipolar pedigrees for genetic studies. In 1997, the four participating sites published a genome scan on the initial set of 97 bipolar pedigrees. Fiftyβsix additional bipolar pedigrees have