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Apparent double defect in C11β and C21-steroid hydroxylation in congenital adrenal hyperplasia

✍ Scribed by M. Finkelstein; Y. Litvin; Y. Mizrachi; G. Neiman; A. Rösler


Book ID
116003278
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
556 KB
Volume
19
Category
Article
ISSN
0022-4731

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The steroid 21-hydroxylase enzyme (P450c21) is a member of the cytochrome P450 gene superfamily and is essential in the synthesis of cortisol and aldosterone. Defects in the P450c21B gene cause congenital adrenal hyperplasia (CAH), a common genetic disorder leading to virilization of newborn females