Dynamic changes in relative cerebral blood volume (rCBV) and apparent diffusion coefficient (ADC) were investigated, using high speed magnetic resonance imaging (MRI) in an acute neonatal rabbit model of hypoxic-ischemic encephalopathy (HIE). Serial rCBV imaging used a magnetic susceptibility blood
Apparent Diffusion Coefficient Pseudonormalization Time in Neonatal Hypoxic-Ischemic Encephalopathy
✍ Scribed by Jeff D. Winter; David S. Lee; Ryan M. Hung; Simon D. Levin; John M. Rogers; R. Terry Thompson; Neil Gelman
- Book ID
- 116825195
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 535 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0887-8994
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## Abstract Hypoxic‐ischemic encephalopathy (HIE) can result from neonatal asphyxia, the pathophysiology of which is poorly understood. We studied the acute evolution of this disease, using magnetic resonance imaging in an established animal model. HIE was induced in neonatal rabbits by a combinati
## Abstract Cerebral apparent diffusion coefficients {ADCs) were determined in nine newborn piglets before and for 48 h after transient hypoxia‐ischemia. Phosphorus MRS revealed severely reduced cerebral energy metabolism during the insult and an apparently complete recovery 2 h after resuscitation