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Apparent absence of serotonin1B receptors in biopsied and post-mortem human brain

✍ Scribed by Johanne Martial; Samarthjia Lal; Michel Dalpé; Andre Olivier; Claude De Montigny; Remi Quirion

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
793 KB
Volume
4
Category
Article
ISSN
0887-4476

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✦ Synopsis

In order to determine if post-mortem delays could account for the apparent absence of 5-HTlB sites reported in human brain, 5-HTIB binding parameters were determined in fresh and fresh-frozen cortical biopsies and compared to results obtained in post-mortem tissues. Binding parameters and in vitro receptor autoradiography were performed by using two different ligands which have been shown to label 5-HTlB sites, namely 13H15-HT, in presence of 100 nM 8-OH-DPAT, and [12511cyanopindolol, in presence of 10 p,M (-)isoproterenol. No specific binding was detected with [1251] cyanopindolol in either fresh cortical biopsies or post-mortem tissues, suggesting that the apparent absence of 5-HTlB receptor sites reported earlier was not related to long post-mortem delays. Some specific labelling was seen with L3H15-HT,

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