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APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: implications for Alzheimer’s disease

✍ Scribed by Hafiz Mohmmad Abdul; Gary L. Wenk; McGann Gramling; Beatrice Hauss-Wegrzyniak; D. Allan Butterfield

Book ID: 116766979
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 98 KB
Volume: 368
Category: Article
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2004.06.077

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## Abstract Glutathione (GSH) is an important endogenous antioxidant found in millimolar concentrations in the brain. GSH levels have been shown to decrease with aging. Alzheimer's disease (AD) is a neurodegenerative disorder associated with aging and oxidative stress. Aβ(1–42) has been shown to in