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APP and BACE1 miRNA genetic variability in risk for Alzheimer's disease

✍ Scribed by Karolien Bettens; Nathalie Brouwers; Helen Van Miegroet; Sebastiaan Engelborghs; Peter De Deyn; Jessie Theuns; Kristel Sleegers; Christine Van Broeckhoven

Book ID
118465514
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
100 KB
Volume
5
Category
Article
ISSN
1552-5260

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APP and BACE1 miRNA genetic variability
APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease
✍ Karolien Bettens; Nathalie Brouwers; Sebastiaan Engelborghs; Helen Van Miegroet; πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 247 KB

Expression levels of the amyloid precursor protein (APP) and b-site amyloid (Ab) cleaving enzyme 1 (BACE1) have been implicated in Alzheimer disease (AD) progression. In a well-characterized Belgian group of 358 AD patients and 462 controls, we examined whether genetic variability in microRNA (miRNA