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Apoptotic Non–β Cells Suppress β Cell Antigen–Reactive T Cells and Induce β Cell Antigen–Specific Regulatory T Cells : Transfusion of Apoptotic Splenic Stromal Cells Prevents Type 1 Diabetes

✍ Scribed by Chang-Qing Xia; Yushi Qiu; Ruihua Peng; Jeannette Lo-Dauer; Michael J. Clare-Salzler

Book ID: 111484835
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 74 KB
Volume: 1150
Category: Article
ISSN: 0890-6564
DOI: 10.1196/annals.1447.038

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## Abstract Treg can suppress autoimmune diseases such as type 1 diabetes, but their __in vivo__ activity during suppression remains poorly characterized. In type 1 diabetes, Treg activity has been demonstrated in the pancreatic lymph node, but little has been studied in the pancreas, the site of a