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Apoptotic Mitochondrial Dysfunction Induced by Benzo(a)pyrene in Liver Epithelial Cells : Role of p53 and pHi Changes

✍ Scribed by LAURENCE HUC; DAVID GILOT; CLAIRE GARDYN; MARY RISSEL; MARIE-THÉRÈSE DIMANCHE-BOITREL; ANDRÉ GUILLOUZO; OLIVIER FARDEL; DOMINIQUE LAGADIC-GOSSMANN


Book ID
111478221
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
848 KB
Volume
1010
Category
Article
ISSN
0890-6564

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Multiple apoptotic pathways induced by p
✍ Laurence Huc; Mary Rissel; Anita Solhaug; Xavier Tekpli; Morgane Gorria; Alicia 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 531 KB

## Abstract Polycyclic aromatic hydrocarbons (PAH), such as benzo[a]pyrene (B[a]P), are ubiquitous genotoxic environmental pollutants. Their DNA‐damaging effects lead to apoptosis induction, through similar pathways to those identified after exposure to other DNA‐damaging stimuli with activation of