𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Apoptotic effect of gossypol on human lymphocytes

✍ Scribed by Erkan Yurtcu; Mehmet Ali Ergun; Adnan Menevse

Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
129 KB
Volume
27
Category
Article
ISSN
1065-6995

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The overall objective of this study was to determine the effect of gossypol on human lymphocytes. Blood samples were taken from healthy donors and lymphocytes were cultured with various concentrations of gossypol (25–150 ΞΌM). The percentage of apoptotic cells was determined by assessing DNA fragmentation by agarose gel electrophoresis; morphological features of apoptosis were assessed by light microscopy. The concentrations of gossypol required to induce apoptosis in human lymphocytes without causing necrosis through cytotoxic effects were between 25–50 ΞΌM.

πŸ“œ SIMILAR VOLUMES

Cytogenetic effect of carboplatin on hum
Cytogenetic effect of carboplatin on human lymphocytes
✍ Tetsu Shinkai; Nagahiro Saijo; Kenji Eguchi; Yasutsuna Sasaki; Tomohide Tamura; πŸ“‚ Article πŸ“… 1988 πŸ› Springer 🌐 English βš– 722 KB

Carboplatin, a second generation cisplatin analogue, was tested for induction of sister chromatid exchange (SCE) as well as chromosomal aberrations in human lymphocytes in vitro and in vivo. A dose-dependent effect was observed for increased frequency of metaphases with SCE (r = 0.984, P less than 0