## Abstract Interferon‐γ (IFN‐γ), as one of interferon family that regulates antiviral, antiproliferative, and immunomodulatory responses, has been implicated for the growth regulation of ovarian cancer cells. However, the molecular mechanisms are not yet fully defined. To analyze detailed mechanis
Apoptotic cells induce dendritic cell-mediated suppression via interferon-γ-induced IDO
✍ Scribed by Charlotte A. Williams; Rachel A. Harry; Julie D. McLeod
- Book ID
- 108782231
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 449 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0019-2805
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## Abstract ## Background Dendritic cell (DC)‐based vaccines have become a promising modality in cancer immunotherapy. However, their ability to initiate tumor antigen‐specific T cell immunity is limited in various negative‐feedback mechanisms. The rapid down‐regulation of chemokines, such as the