APOPTOTIC AND MITOTIC ACTIVITY IN SQUAMOUS CELL CARCINOMA CELLS AFTER COMBINED MODALITY TREATMENT WITH γ-IRRADIATION AND DIBROMODULCITOL

✍ Scribed by H. Kraxner; L. Tamás; G. Sáfrány; O. Ribári; I. Oláh; E. Hidvégi; G. Répássy; B. Szende

• Book ID: 102569356
• Publisher: Elsevier Science
• Year: 2001
• Tongue: English
• Weight: 235 KB
• Volume: 25
• Category: Article
• ISSN: 1065-6995
• DOI: 10.1006/cbir.2000.0707

✦ Synopsis

A-431 squamous cell carcinoma cells were treated in vitro with either 4 Gy radiation of 15 (or 45) microg/ml dibromodulcitol (DBD), as well as with combined 4 Gy irradiation and DBD, with the latter as either a pretreatment or post-treatment. DBD alone or in combination with radiation had a greater effect on cell proliferation than the effect of radiation alone. The difference is due to a higher level of apoptosis induced by DBD, especially in conjunction with radiation. Such a combination may therefore be useful in the treatment of squamous cell carcinoma, which in general responds poorly to radiation therapy.