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Apoptosis of vascular smooth muscle cells induced by photodynamic therapy with protoporphyrin IX

✍ Scribed by Qingsong Li; Jiali Cheng; Chenghai Peng; Zhitao Li; Sa Shi; Huijuan Liang; Ye Tian; Zhiguo Zhang; Wenwu Cao

Book ID: 116299434
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 798 KB
Volume: 391
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2009.11.003

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## Abstract We have shown previously that nitric‐oxide (NO) can induce apoptosis of vascular smooth muscle cells (VSMCs) and that the NO‐induced apoptosis is accompanied by an increase in arachidonic acid release via cytoplasmic Ca^2+^‐dependent phospholipase A~2~ (cPLA~2~). We have evidence that d