Recent research has yielded a dramatic increase in the number of connections between oncogenesis and the proteins which regulate the cell cycle. Three classes of protein which inhibit the activity of cyclin-dependent kinases (CDKs) have emerged as potential targets for oncogenic inactivation. p16 an
β¦ LIBER β¦
Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors
β Scribed by Subhra Mohapatra; Baoky Chu; Xiuhua Zhao; Julie Djeu; Jin Q. Cheng; W. Jackson Pledger
- Book ID
- 116307639
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 806 KB
- Volume
- 41
- Category
- Article
- ISSN
- 1357-2725
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## Background: Downregulation of genes which negatively control cell cycle progression represents a possible mechanism for prostate tumorigenesis. we examined the expression levels of the p16, p15, p14, and retinoblastoma-susceptibility (rb) genes in primary prostate cancers and human prostate canc