Apoptosis of lymphocytes induced by glucocorticoids and relationship to therapeutic efficacy in patients with systemic lupus erythematosus
β Scribed by Manami Seki; Chifuyu Ushiyama; Noriyuki Seta; Kaori Abe; Toru Fukazawa; Junichi Asakawa; Yoshinari Takasaki; Hiroshi Hashimoto
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 904 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0004-3591
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Pathogenesis of autoimmune diseases like systemic lupus erythematosus (SLE) is unresolved. Dysregulation of programmed cell death is discussed as a pathogenetic factor. We have previously shown that increased in vitro apoptosis of cultured peripheral blood mononuclear cells (PBMC) is nonspecific for
Decreased interleukin-2 (IL-2) production by lymphocytes in vitro has previously been demonstrated in patients with systemic lupus erythematosus (SLE). In the present study, we examined whether inhibitory factors in SLE patient sera are involved in defective IL-2 production. Our results indicate tha