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Apoptosis of human carcinoma cells in the presence of inhibitors of glycosphingolipid biosynthesis: I. Treatment of Colo-205 and SKBR3 cells with isomers of PDMP and PPMP

✍ Scribed by Subhash Basu; Rui Ma; Brian Mikulla; Mathew Bradley; Christopher Moulton; Manju Basu; Sipra Banerjee; Jin-ichi Inokuchi


Book ID
111583684
Publisher
Springer US
Year
2003
Tongue
English
Weight
423 KB
Volume
20
Category
Article
ISSN
1573-4986

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## Abstract ## BACKGROUND Topotecan (9‐dimethylaminomethyl‐10‐hydroxycampthothecin) is a new topoisomerase I inhibitor with promising efficacy in the treatment of patients with small cell lung carcinoma (SCLC). Combination with a topoisomerase II inhibitor may potentate the therapeutic effect of t