## Abstract The carcinogenesis of human papillomaviruses type 16 (HPVβ16) is mainly due to its two oncoproteins, E6 and E7. Their carcinogenic features in term of their relationship with Bclβ2 family are still unclear. We thus aimed to analyze the expression of Bclβ2 family members, Bclβ2, Bax, and
Apoptosis of HeLa cells inhibited by human papillomavirus type 16 E6 protein interacting with hDaxx
β Scribed by Aitao He; Xin Wang; Cuiming Zhu; Hengling Cai; Yanping Wan
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 151 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1610-1979
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## Abstract In our study, we show that expression of HPVβ16 E6 sensitizes TNFβinduced cytotoxicity of human ovarian cancer cell line A2780. This effect is not related to a different number of TNF receptors present on cell membrane. The major induction of massive apoptosis induced by TNF is not p53β
We and others have previously reported that human papillomavirus (HPV)-16 E6 protein expression sensitizes certain cell types to apoptosis. To confirm that this sensitization occurred in HPV's natural host cells, and to explore the mechanism(s) of sensitization, we infected human keratinocytes (HKCs