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Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTPα and src RNAi

✍ Scribed by Xinmin Zheng; Ross J. Resnick; David Shalloway

Publisher
John Wiley and Sons
Year
2008
Tongue
French
Weight
410 KB
Volume
122
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

We show that siRNA‐mediated suppression of protein tyrosine phosphatase α (PTPα) reduces Src activity 2 to 4‐fold in breast, colon and other human cancer cell lines. Src and PTPα RNAi induced apoptosis in estrogen receptor (ER)‐negative breast cancer and colon cancer cells, but not in immortalized noncancerous breast cells, ER‐positive breast cancer cells or other cancer cell types tested. RNAi of other Src family members (Fyn and Yes) or of PTP1B, a phosphatase previously suggested to be an activator of Src in breast cancer, had no effect. Although further tests with primary tumor tissues are required, the unexpected correlation between ER status and Src/PTPα dependence in breast cancer cell lines may be important for planning therapeutic strategies, and the insensitivity of normal breast cells to the RNAi highlights the potential of PTPα, which may be easier to target than Src, as a therapeutic target in ER‐negative breast cancer. © 2008 Wiley‐Liss, Inc.

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