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Apoptosis of activated peripheral T cells

✍ Scribed by L Genestier; N Bonnefoy-Berard; J.-P Revillard


Book ID
117237880
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
80 KB
Volume
31
Category
Article
ISSN
0041-1345

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Clonal deletion represents an important mechanism for the establishment of tolerance, by the elimination of autoreactive T cells. Deletion is accomplished by programmed cell death, termed apoptosis, induced by mobilization of the T cell receptor (TCR) on both thymocytes and mature T cells. The mecha