✦ LIBER ✦

Apoptosis is not the mechanism of cell death of muscle fibers in human muscular dystrophies and inflammatory myopathies

✍ Scribed by Montserrat Olivé; Juan Antonio Martinez-Matos; Jordi Montero; Isidro Ferrer

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 217 KB
Volume: 20
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199710)20:10<1328::aid-mus20>3.0.co;2-y

No coin nor oath required. For personal study only.

✦ Synopsis

Muscle biopsies from patients affected by muscular dystrophies and polymyositis were processed with the method of in situ labeling of nuclear DNA fragmentation in order to assess whether apoptosis occurs in these diseases. Apoptotic nuclei were seen in the mononuclear cell infiltrates in inflammatory myopathies but not in dying muscle fibers, thus confirming the general opinion that death of muscle fibers in human diseases is not produced by a mechanism of apoptosis.