Apoptosis-inducing neurotoxicity of dopamine and its metabolites via reactive quinone generation in neuroblastoma cells

Genistein selectively potentiates arseni

Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK)

✍ Yolanda Sánchez; Donna Amrán; Carlos Fernández; Elena de Blas; Patricio Aller 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 626 KB

## Abstract The observation that genistein may behave as a pro‐oxidant agent lead us to examine the capacity of this isoflavone to modulate the toxicity of the oxidation‐sensitive anti‐leukemic agent arsenic trioxide (ATO), and for comparison other anti‐tumor drugs. Co‐treatment with genistein incr