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Apoptosis Inducing Factor and PARP-Mediated Injury in the MPTP Mouse Model of Parkinson's Disease

✍ Scribed by HONGMIN WANG; MIKA SHIMOJI; SEONG-WOON YU; TED M. DAWSON; VALINA L. DAWSON

Book ID
111398314
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
993 KB
Volume
991
Category
Article
ISSN
0890-6564

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This is the first study to investigate the potential protective effects of the lipophilic kavapyrone (+/-)-kavain in the experimental MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) model of Parkinson's disease (PD). Male C57BL/6 mice were treated with (+/-)-kavain (50, 100, or 200 mg/kg i.p.) o