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Apoptosis induced by baicalin involving up-regulation of P53 and bax in MCF-7 cells

✍ Scribed by Wang, Ning; Tang, Li-Jian; Zhu, Guo-Qi; Peng, Dai-Yin; Wang, Lei; Sun, Fa-Neng; Li, Qing-Lin


Book ID
120265358
Publisher
Taylor and Francis Group
Year
2008
Tongue
English
Weight
736 KB
Volume
10
Category
Article
ISSN
1028-6020

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## Abstract Jurkat T‐lymphocytes lack p53 and Bax but contain p73 and Bid and are killed by etoposide (ETO). With ETO c‐abl is phosphorylated and phosphorylated p73 increased. Translocation of full‐length Bid to mitochondria follows, with induction of the mitochondrial permeability transition (MPT)