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Apoptosis in vascular smooth muscle accompanied by increases in arachidonic acid and ceramide

✍ Scribed by Edward F. Labelle; Ken Wilson; Cyril Pilane

Book ID
114101208
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
54 KB
Volume
59
Category
Article
ISSN
0090-6980

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NO induced apoptosis of vascular smooth
NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase
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## Abstract We have shown previously that nitric‐oxide (NO) can induce apoptosis of vascular smooth muscle cells (VSMCs) and that the NO‐induced apoptosis is accompanied by an increase in arachidonic acid release via cytoplasmic Ca^2+^‐dependent phospholipase A~2~ (cPLA~2~). We have evidence that d

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## Abstract Apoptosis of vascular smooth muscle cells (VSMCs) has recently drawn a lot of interest in various laboratories due to its importance in atherogenesis. We have shown previously that nitric‐oxide (NO) can induce apoptosis of VSMCs and that the NO‐induced apoptosis is accompanied by an inc

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## Abstract The role of eicosanoids in atherogenesis has not been thouroughly explained. This is partly due to the numerous eicosanoids and the variable effects that each has on different systems. Apoptosis of vascular smooth muscle cells has been shown to play a role in the atherosclerotic disease

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✍ Cyril M. Pilane; Edward F. LaBelle πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 218 KB πŸ‘ 1 views

## Abstract Apoptosis has been shown to occur in vascular smooth muscle cells during the development of atherosclerosis. In order to investigate the possible role of arachidonic acid during apoptosis in vascular smooth muscle, we induced apoptosis in cultured rat aortal smooth muscle cells (SMCs) b