A dual role of p21 in liver regeneration
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Christian Liedtke; Christian Trautwein
📂
Article
📅
2008
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John Wiley and Sons
🌐
English
⚖ 104 KB
Accumulation of toxic metabolites in hereditary tyrosinemia type I (HT1) patients leads to chronic DNA damage and the highest risk for hepatocellular carcinomas (HCCs) of any human disease. Here we show that hepatocytes of HT1 mice exhibit a profound cell-cycle arrest that, despite concomitant apopt