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Apoptosis-associated gene expression in HIV-infected patients in response to successful antiretroviral therapy

✍ Scribed by Emanuela Balestrieri; Sandro Grelli; Claudia Matteucci; Antonella Minutolo; Gabriella d'Ettorre; Fiorella Di Sora; Francesco Montella; Vincenzo Vullo; Stefano Vella; Cartesio Favalli; Beatrice Macchi; Antonio Mastino

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
141 KB
Volume
79
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

The simultaneous expression of 19 apoptosis‐related genes was analyzed by RNA‐protection assay in peripheral blood mononuclear cells of HIV‐infected patients before and during successful antiretroviral therapy (ART). After 12 months of therapy, the expression of the pro‐apoptotic genes FAS, FAS‐L, FAF‐1, FADD, CASPASE‐8, DR3, TRAIL, TNFR‐1, TRADD, and BAX was significantly downregulated with respect to time 0, while that of BCL‐2, BCL‐XL, and MCL‐1 was significantly upregulated. The data suggest that inhibition of cell death in HIV‐positive patients under successful therapy is the result of a complex network of multifactor signaling, correlated with both death and survival of lymphocytes. J. Med. Virol. 79:111–117, 2007. © 2006 Wiley‐Liss, Inc.

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