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Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophosphamide-accelerated diabetes

โœ Scribed by P. Augstein; A. G. Elefanty; J. Allison; L. C. Harrison


Book ID
105822060
Publisher
Springer
Year
1998
Tongue
English
Weight
417 KB
Volume
41
Category
Article
ISSN
0012-186X

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The development of diabetes in non-obese diabetic (NOD) mice, which normally takes between 3 and 7 months, can be accelerated by cyclophosphamide (CY) injections, with rapid progression to diabetes within only 2ยฑ3 weeks. This insulin-dependent diabetes mellitus (IDDM) can be prevented or delayed in