Age-related macular degeneration (AMD) is a frequent, multifactorial disease of the central retina and a major cause of irreversible vision loss in industrialized countries. Apolipoprotein E (APOE) has been consistently associated with AMD, particularly its two functional isoforms E2 (predisposing)
Apolipoprotein E genotype and risk for development of cataract and age-related macular degeneration
✍ Scribed by Øygunn A. Utheim; Jon Ståle Ritland; Tor P. Utheim; Thomas Espeseth; Stian Lydersen; Helge Rootwelt; Svein Ove Semb; Tor Elsås
- Book ID
- 109340561
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2008
- Tongue
- English
- Weight
- 88 KB
- Volume
- 86
- Category
- Article
- ISSN
- 1755-375X
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## Abstract Age‐related macular degeneration (AMD) is the leading cause of visual impairment and blindness among the elderly in Western countries. Genetic factors, age, cigarette smoking, nutrition, and exposure to light have been identified as AMD risk factors. In this study, we investigated the a
Progression of age-related macular degeneration (AMD), the leading cause of blindness in the elderly, was followed in a cohort of 238 individuals from a single center. Individuals with an epsilon (e)2 genotype (c.526C4T of reference sequence NM -000041.2) of the apolipoprotein (APOE) gene were found