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Apolipoprotein AIV codon 360 mutation increases with human aging and is not associated with Alzheimer's disease

✍ Scribed by Aksam Merched; Yongjing Xia; Anna Papadopoulou; Gérard Siest; Sophie Visvikis


Book ID
117476453
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
42 KB
Volume
242
Category
Article
ISSN
0304-3940

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It was suggested that in contrast to the E4 allele, the E2 allele of the apolipoprotein E gene (APOE"2) has a protective effect for late-onset Alzheimer's disease and early-onset Alzheimer's disease (EOAD). We studied the role of the APOE\*2 allele in the pathogenesis of EOAD in a Dutch population-b