Aplysinol from laurencia decidua: crystal structure and Absolute stereochemistry
โ Scribed by Joyce A. McMillan; Iain C. Paul; Salvatore Caccamese; Kenneth L. Rinehart Jr.
- Publisher
- Elsevier Science
- Year
- 1976
- Tongue
- French
- Weight
- 234 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
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The crystal structure of a derivative of the antiviral and antitumour compound eudistomin K la has been determined, confirming the proposed structure and stereochemistry. The conformation found for the oxathiazepine ring in the solid state is similar to that proposed for the solution state from nmr
C15H2602Br2' involving ring isomerization, m/e 4CC, 398 and 396 (M+), T 9.12 (3H, br. t), 9.04 (3H, t, J=7), 7.94 (lH, m), 7.74 (2H, m), 7.42 (1H quintet), 6.4-5.8 (6H, m), which was then degradated to an unsaturated glycol (V) \*dith Zn-acetic acid as described in previous report (1).